Cardiovascular diseases are the leading threats to human lives, owing to the limited regenerative capacities of human cardiovascular systems. By contrast, lower vertebrates like zebrafish can fully regenerate major organs including the heart post injuries. Understanding the fundamental mechanisms of tissue regeneration in lower vertebrates can establish new approaches to regenerative medicine. The central goal of our lab is to unveal the mechanisms of tissue regeneration and develop new methods to boost regeneration capacities. Our current research is focused on three major directions:

1. Define the function and regulation of nutrient and energy metabolisms during cardiovascular development and regeneration.
2. Characterize novel genetic and pharmacological regulators to boost tissue regeneration.
3. Generate animal models for human cardiovascular diseases.

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